Aine O'Toole

Research Interests

Publications

Total publications: 13
Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity.
Thomson EC, Rosen LE, Shepherd JG, Spreafico R, da Silva Filipe A, Wojcechowskyj JA, Davis C, Piccoli L, Pascall DJ, Dillen J, Lytras S, Czudnochowski N, Shah R, Meury M, Jesudason N, De Marco A, Li K, Bassi J, O'Toole A, Pinto D, Colquhoun RM, Culap K, Jackson B, Zatta F, Rambaut A, Jaconi S, Sreenu VB, Nix J, Zhang I, Jarrett RF, Glass WG, Beltramello M, Nomikou K, Pizzuto M, Tong L, Cameroni E, Croll TI, Johnson N, Di Iulio J, Wickenhagen A, Ceschi A, Harbison AM, Mair D, Ferrari P, Smollett K, Sallusto F, Carmichael S, Garzoni C, Nichols J, Galli M, Hughes J, Riva A, Ho A, Schiuma M, Semple MG, Openshaw PJM, Fadda E, Baillie JK, Chodera JD, Rihn SJ, Lycett SJ, Virgin HW, Telenti A, Corti D, Robertson DL, Snell G, The ISARIC4C Investigators & the COVID-19 Genomics UK (COG-UK) Consortium (2021) Cell 184, 1171-1187.
Addendum: A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology.
Rambaut A, Holmes EC, O'Toole Á, Hill V, McCrone JT, Ruis C, du Plessis L & Pybus OG (2021) Nature microbiology 6, 415.
Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK.
du Plessis L, McCrone JT, Zarebski AE, Hill V, Ruis C, Gutierrez B, Raghwani J, Ashworth J, Colquhoun R, Connor TR, Faria NR, Jackson B, Loman NJ, O'Toole Á, Nicholls SM, Parag KV, Scher E, Vasylyeva TI, Volz EM, Watts A, Bogoch II, Khan K, Aanensen DM, Kraemer MUG, Rambaut A & Pybus OG (2021) Science 371, 708-712.
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.
Volz E, Hill V, McCrone JT, Price A, Jorgensen D, O'Toole Á, Southgate J, Johnson R, Jackson B, Nascimento FF, Rey SM, Nicholls SM, Colquhoun RM, da Silva Filipe A, Shepherd J, Pascall DJ, Shah R, Jesudason N, Li K, Jarrett R, Pacchiarini N, Bull M, Geidelberg L, Siveroni I, COG-UK Consortium, Goodfellow I, Loman NJ, Pybus OG, Robertson DL, Thomson EC, Rambaut A & Connor TR (2021) Cell 184, 64-75.
Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England.
Volz E, Mishra S, Chand M, Barrett JC, Johnson R, Geidelberg L, Hinsley WR, Laydon DJ, Dabrera G, O'Toole Á, Amato R, Ragonnet-Cronin M, Harrison I, Jackson B, Ariani CV, Boyd O, Loman NJ, McCrone JT, Gon?alves S, Jorgensen D, Myers R, Hill V, Jackson DK, Gaythorpe K, Groves N, Sillitoe J, Kwiatkowski DP, Flaxman S, Ratmann O, Bhatt S, Hopkins S, Gandy A, Rambaut A, Ferguson NM & The COVID-19 Genomics UK (COG-UK) consortium (2021) Nature
Genomic epidemiology reveals multiple introductions of SARS-CoV-2 from mainland Europe into Scotland.
da Silva Filipe A, Shepherd JG, Williams T, Hughes J, Aranday-Cortes E, Asamaphan P, Ashraf S, Balcazar C, Brunker K, Campbell A, Carmichael S, Davis C, Dewar R, Gallagher MD, Gunson R, Hill V, Ho A, Jackson B, James E, Jesudason N, Johnson N, McWilliam Leitch EC, Li K, MacLean A, Mair D, McAllister DA, McCrone JT, McDonald SE, McHugh MP, Morris AK, Nichols J, Niebel M, Nomikou K, Orton RJ, O'Toole Á, Palmarini M, Parcell BJ, Parr YA, Rambaut A, Rooke S, Shaaban S, Shah R, Singer JB, Smollett K, Starinskij I, Tong L, Sreenu VB, Wastnedge E, Holden MTG, Robertson DL, Templeton K, Thomson EC & The COVID-19 Genomics UK (COG-UK) Consortium (2021) Nature Microbiology 6, 112-122.
Accommodating individual travel history and unsampled diversity in Bayesian phylogeographic inference of SARS-CoV-2.
Lemey P, Hong SL, Hill V, Baele G, Poletto C, Colizza V, O'Toole Á, McCrone JT, Andersen KG, Worobey M, Nelson MI, Rambaut A & Suchard MA (2020) Nature Communications 11, 5110.
A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology.
Rambaut A, Holmes EC, O'Toole Á, Hill V, McCrone JT, Ruis C, du Plessis L & Pybus OG (2020) Nature Microbiology 5, 1403-1407.
COVID-19 in health-care workers in three hospitals in the south of the Netherlands: a cross-sectional study.
Sikkema RS, Pas SD, Nieuwenhuijse DF, O'Toole Á, Verweij JJ, van der Linden A, Chestakova I, Schapendonk C, Pronk M, Lexmond P, Bestebroer T, Overmars RJ, van Nieuwkoop S, van den Bijllaardt W, Bentvelsen RG, van Rijen MML, Buiting AGM, van Oudheusden AJG, Diederen BM, Bergmans AMC, van der Eijk A, Molenkamp R, Rambaut A, Timen A, Kluytmans JAJW, Oude Munnink BB, Kluytmans van den Bergh MFQ & Koopmans MPG (2020) The Lancet Infectious Diseases 20, 1273-1280.
Author Correction: Rapid SARS-CoV-2 whole-genome sequencing and analysis for informed public health decision-making in the Netherlands (Nature Medicine, (2020), 26, 9, (1405-1410), 10.1038/s41591-020-0997-y).
Oude Munnink BB, Nieuwenhuijse DF, Stein M, O'Toole Á, Haverkate M, Mollers M, Kamga SK, Schapendonk C, Pronk M, Lexmond P, van der Linden A, Bestebroer T, Chestakova I, Overmars RJ, van Nieuwkoop S, Molenkamp R, van der Eijk AA, GeurtsvanKessel C, Vennema H, Meijer A, Rambaut A, van Dissel J, Sikkema RS, Timen A, Koopmans M, Oudehuis GJAPM, Schinkel J, Kluytmans J, Kluytmans-van den Bergh M, van den Bijllaardt W, Berntvelsen RG, van Rijen MML, Schneeberger P, Pas S, Diederen BM, Bergmans AMC, van der Eijk PAV, Verweij JJ, Buiting AGN, Streefkerk R, Aldenkamp AP, de Man P, Koelemal JGM, Ong D, Paltansing S, Veassen N, Sleven J, Bakker L, Brockhoff H, Rietveld A, Slijkerman Megelink F, Cohen Stuart J, de Vries A, van der Reijden W, Ros A, Lodder E, Verspui-van der Eijk E, Huijskens I, Kraan EM, van der Linden MPM, Debast SB, Naiemi NA, Kroes ACM, Damen M, Dinant S, Lekkerkerk S, Pontesilli O, Smit P, van Tienen C, Godschalk PCR, van Pelt J, Ott A, van der Weijden C, Wertheim H, Rahamat-Langendoen J, Reimerink J, Bodewes R, Duizer E, van der Veer B, Reusken C, Lutgens S, Schneeberger P, Hermans M, Wever P, Leenders A, ter Waarbeek H, Hoebe C & The Dutch-Covid-19 response team (2020) Nature Medicine 26, 1802.
Rapid and sensitive direct detection and identification of poliovirus from stool and environmental surveillance samples by use of nanopore sequencing.
Shaw AG, Majumdar M, Troman C, O'Toole Á, Benny B, Abraham D, Praharaj I, Kang G, Sharif S, Alam MM, Shaukat S, Angez M, Khurshid A, Mahmood N, Arshad Y, Rehman L, Mujtaba G, Akthar R, Salman M, Klapsa D, Hajarha Y, Asghar H, Bandyopadhyay A, Rambaut A, Martin J & Grassly N (2020) Journal of Clinical Microbiology 58, e00920.
Rapid SARS-CoV-2 whole-genome sequencing and analysis for informed public health decision-making in the Netherlands.
Oude Munnink BB, Nieuwenhuijse DF, Stein M, O'Toole Á, Haverkate M, Mollers M, Kamga SK, Schapendonk C, Pronk M, Lexmond P, van der Linden A, Bestebroer T, Chestakova I, Overmars RJ, van Nieuwkoop S, Molenkamp R, van der Eijk AA, GeurtsvanKessel C, Vennema H, Meijer A, Rambaut A, van Dissel J, Sikkema RS, Timen A, Koopmans M, Oudehuis GJAPM, Schinkel J, Kluytmans J, Kluytmans-van den Bergh M, van den Bijllaardt W, Berntvelsen RG, van Rijen MML, Schneeberger P, Pas S, Diederen BM, Bergmans AMC, van der Eijk PAV, Verweij J, Buiting AGN, Streefkerk R, Aldenkamp AP, de Man P, Koelemal JGM, Ong D, Paltansing S, Veassen N, Sleven J, Bakker L, Brockhoff H, Rietveld A, Slijkerman Megelink F, Cohen Stuart J, de Vries A, van der Reijden W, Ros A, Lodder E, Verspui-van der Eijk E, Huijskens I, Kraan EM, van der Linden MPM, Debast SB, Naiemi NA, Kroes ACM, Damen M, Dinant S, Lekkerkerk S, Pontesilli O, Smit P, van Tienen C, Godschalk PCR, van Pelt J, Ott A, van der Weijden C, Wertheim H, Rahamat-Langendoen J, Reimerink J, Bodewes R, Duizer E, van der Veer B, Reusken C, Lutgens S, Schneeberger P, Hermans M, Wever P, Leenders A, ter Waarbeek H, Hoebe C & The Dutch-Covid-19 response team (2020) Nature Medicine 26, 1405-1410.
Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020.
Alm E, Broberg EK, Connor T, Hodcroft EB, Komissarov AB, Maurer-Stroh S, Melidou A, Neher RA, O'Toole Á, Pereyaslov D & The WHO European Region sequencing laboratories and GISAID EpiCoV group (2020) Eurosurveillance 25, 2001410.
 
Andrew Rambaut, 2007